Neuronal Differentiation and Synaptogenesis in Retinoblastoma
نویسندگان
چکیده
منابع مشابه
Neuronal differentiation and synaptogenesis in retinoblastoma.
Retinoblastomas initiate in the developing retina in utero and are diagnosed during the first few years of life. We have recently generated a series of knockout mouse models of retinoblastoma that recapitulate the timing, location, and progression of human retinoblastoma. One of the most important benefits of these preclinical models is that we can study the earliest stages of tumor initiation ...
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amacrine cells (using a new method they developed, termed " photofilling "), MacNeil and Masland were able to describe at least 26 different types of this neuron, including the four major types previously described (Figure 1). They found that most of the cell types " tiled " the retina very efficiently; namely, the amacrine cells of a given class populated the retina at a density such that Over...
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Tumor cells can be induced to differentiate in vitro by biochemical manipulation of their culture environment. In the studies described here, the effects of medium conditioned by human retinal pigmented epithelial (RPE) cells on Y79 human retinoblastoma cells have been examined. RPE-conditioned medium in conjunction with laminin and a poly-D-lysine substratum is observed to induce neuronal diff...
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ژورنال
عنوان ژورنال: Cancer Research
سال: 2007
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-06-3754